The design of self-replicating helical peptides

被引：50

作者：

Issac, R ^{[1
]}

Ham, YW ^{[1
]}

Chmielewski, J ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2001年 / 11卷 / 04期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0959-440X(00)00233-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The self-assembly of helical peptides and information transfer through autocatalysis and cross-catalysis are the foundation of peptide-based molecular evolution models. Many fundamental properties of living systems, such as environmental sensitivity, chiroselectivity, cross-catalysis, dynamic error correction and conditional selection, are exhibited by various self-replicating peptide systems. Recently, advances have been made in the design of peptide systems with autocatalytic and cross-catalytic properties.

引用

收藏

页码：458 / 463

页数：6

相关论文

共 21 条

[1] SYNTHESIS OF PROTEINS BY NATIVE CHEMICAL LIGATION [J].

DAWSON, PE ;

MUIR, TW ;

CLARKLEWIS, I ;

KENT, SBH .

SCIENCE, 1994, 266 (5186) :776-779

[2] A de novo designed peptide ligase:: A mechanistic investigation [J].

Kennan, AJ ;

Haridas, V ;

Severin, K ;

Lee, DH ;

Ghadiri, MR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (09) :1797-1803

[3] The helix-destabilizing propensity scale of D-amino acids: The influence of side chain steric effects [J].

Krause, E ;

Bienert, M ;

Schmieder, P ;

Wenschuh, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (20) :4865-4870

[4] A self-replicating peptide [J].

Lee, DH ;

Granja, JR ;

Martinez, JA ;

Severin, K ;

Ghadiri, MR .

NATURE, 1996, 382 (6591) :525-528

[5] Emergence of symbiosis in peptide self-replication through a hypercyclic network [J].

Lee, DH ;

Severin, K ;

Yokobayashi, Y ;

Ghadiri, MR .

NATURE, 1997, 390 (6660) :591-594

[6] CHEMICAL SELF-REPLICATION OF PALINDROMIC DUPLEX DNA [J].

LI, T ;

NICOLAOU, KC .

NATURE, 1994, 369 (6477) :218-221

[7] Surface-promoted replication and exponential amplification of DNA analogues [J].

Luther, A ;

Brandsch, R ;

von Kiedrowski, G .

NATURE, 1998, 396 (6708) :245-248

[8] Peptide and the origin of life [J].

Rode, BM .

PEPTIDES, 1999, 20 (06) :773-786

[9] A chiroselective peptide replicator [J].

Saghatelian, A ;

Yokobayashi, Y ;

Soltani, K ;

Ghadiri, MR .

NATURE, 2001, 409 (6822) :797-801

[10]

Severin K, 1998, ANGEW CHEM INT EDIT, V37, P126, DOI 10.1002/(SICI)1521-3773(19980202)37:1/2<126::AID-ANIE126>3.0.CO