One-pot reaction to synthesize biocompatible magnetite nanoparticles

被引：428

作者：

Li, Z

Wei, L

Gao, MY

Lei, H

机构：

[1] Chinese Acad Sci, Inst Chem, Key Lab Colloid,Interface Sci & Chem Thermodynam, Beijing 100080, Peoples R China

[2] Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China

来源：

ADVANCED MATERIALS | 2005年 / 17卷 / 08期

关键词：

D O I：

10.1002/adma.200401545

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biocompatible magnetite nanocrystals (see Figure) are prepared by thermal decomposition of ferric triacetylacetonate in 2-pyrrolidone in the presence of monocarboxyl-terminated poly(ethylene glycol) (MPEG-COOH). The results reveal that MPEG is covalently bound to the nanocrystal surface by COOH groups. Magnetic resonance imaging (MRI) experiments indicate that the coated nanocrystals are potential MRI contrast agents due to their excellent water solubility and biocompatibility.

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页码：1001 / +

页数：6

相关论文

共 21 条

[1] Functionalisation of magnetic nanoparticles for applications in biomedicine [J].

Berry, CC ;

Curtis, ASG .

JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2003, 36 (13) :R198-R206

[2] Using biofunctional magnetic nanoparticles to capture vancomycin-resistant enterococci and other gram-positive bacteria at ultralow concentration [J].

Gu, HW ;

Ho, PL ;

Tsang, KWT ;

Wang, L ;

Xu, B .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (51) :15702-15703

[3]

Harris J. M., 1992, POLYETHYLENE GLYCOL

[4] Covalent coupling of antibodies to self-assembled monolayers of carboxy-functionalized poly(ethylene glycol): Protein resistance and specific binding of biomolecules [J].

Herrwerth, S ;

Rosendahl, T ;

Feng, C ;

Fick, J ;

Eck, W ;

Himmelhaus, M ;

Dahint, R ;

Grunze, M .

LANGMUIR, 2003, 19 (05) :1880-1887

[5] Presentation of a new magnetic field therapy system for the treatment of human solid tumors with magnetic fluid hyperthermia [J].

Jordan, A ;

Scholz, R ;

Maier-Hauff, K ;

Johannsen, M ;

Wust, P ;

Nadobny, J ;

Schirra, H ;

Schmidt, H ;

Deger, S ;

Loening, S ;

Lanksch, W ;

Felix, R .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2001, 225 (1-2) :118-126

[6]

Josephson L, 2001, ANGEW CHEM INT EDIT, V40, P3204, DOI 10.1002/1521-3773(20010903)40:17<3204::AID-ANIE3204>3.0.CO

[7]

2-H

[8] Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells [J].

Lewin, M ;

Carlesso, N ;

Tung, CH ;

Tang, XW ;

Cory, D ;

Scadden, DT ;

Weissleder, R .

NATURE BIOTECHNOLOGY, 2000, 18 (04) :410-414

[9] One-pot reaction to synthesize water-soluble magnetite nanocrystals [J].

Li, Z ;

Chen, H ;

Bao, HB ;

Gao, MY .

CHEMISTRY OF MATERIALS, 2004, 16 (08) :1391-1393

[10] Self-assembled monolayer coatings on nanosized magnetic particles using 16-mercaptohexadecanoic acid [J].

Liu, QX ;

Xu, ZH .

LANGMUIR, 1995, 11 (12) :4617-4622