Immunoglobulin locus silencing and allelic exclusion

被引:45
作者
Corcoran, AE [1 ]
机构
[1] Babraham Inst, Lab Chromatin & Gene Express, Cambridge CB2 4AT, England
基金
英国生物技术与生命科学研究理事会;
关键词
allelic exclusion; immunoglobulin; locus contraction; monoallelic silencing; heterochromatin;
D O I
10.1016/j.smim.2005.01.002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Lymphocytes are characterised by monoclonal expression of antigen receptors. This is achieved by silencing of one of two homologous antigen receptor alleles, a process known as allelic exclusion. This process is regulated both before and after V(D)J recombination, by a variety of mechanisms. These include nuclear localisation, changes in chromatin structure and histone modifications, non-coding sense and antisense RNA transcription, epigenetic alterations at the DNA level, feedback signalling from expressed alleles, locus contraction and decontraction, recruitment to heterochromatin. This review will focus on recent advances in the immunoglobulin heavy and kappa light chain loci. The current picture is of a complex, temporally ordered sequence of events, in which these loci share many contributory mechanisms, but clear and intriguing differences are emerging. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:141 / 154
页数:14
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