LiveBench-8: The large-scale, continuous assessment of automated protein structure prediction

被引:76
作者
Rychlewski, L
Fischer, D
机构
[1] SUNY Coll Buffalo, Ctr Excellence Bioinformat & Comp Sci & Engn, Buffalo, NY 14203 USA
[2] BioInfoBank Inst, PL-60744 Poznan, Poland
[3] Ben Gurion Univ Negev, Dept Comp Sci, IL-84015 Beer Sheva, Israel
关键词
protein structure prediction; LiveBench; CAFASP;
D O I
10.1110/ps.04888805
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We present the results of the evaluation of the latest LiveBench-8 experiment. These results provide a snapshot view of the state of the art in automated protein structure prediction, just before the 2004 CAFASP-4/CASP-6 experiments begin. The last CAFASP/CASP experiments demonstrated that automated meta-predictors entail a significant advance in the field, already challenging most human expert predictors. LiveBench-8 corroborates the superior performance of meta-predictors, which are able to produce useful predictions for over one-half of the test targets. More importantly, LiveBench-8 identifies a handful of recently developed autonomous (nonmeta) servers that perform at the very top, suggesting that further progress in the individual methods has recently been obtained.
引用
收藏
页码:240 / 245
页数:6
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