Syntheses of imidazole-acridine conjugates as ribonuclease A mimics

被引：28

作者：

Lorente, A

Espinosa, JF

FernandezSaiz, M

Lehn, JM

Wilson, WD

Zhong, YY

机构：

[1] COLL FRANCE,F-75005 PARIS,FRANCE

[2] GEORGIA STATE UNIV,DEPT CHEM,ATLANTA,GA 30303

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 25期

关键词：

D O I：

10.1016/0040-4039(96)00843-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

As a result of efforts to mimic the activity of RNase A we report the syntheses of two novel molecules 1 and 2 containing imidazole residues conjugated to an acridine, a well known intercalator and as such these molecules simultaneously have substrate recognition and potential catalytic ability. t-RNA cleavage by I and 2 is reported. Copyright (C) 1996 Elsevier Science Ltd

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页码：4417 / 4420

页数：4

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