Resolving sorting mechanisms into exosomes

被引：69

作者：

Stoorvogel, Willem ^{[1
]}

机构：

[1] Univ Utrecht, Fac Vet Med, Dept Biochem & Cell Biol, NL-3584 CM Utrecht, Netherlands

来源：

CELL RESEARCH | 2015年 / 25卷 / 05期

关键词：

EXTRACELLULAR VESICLES; BIOGENESIS; CD63; ALIX;

D O I：

10.1038/cr.2015.39

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The complexity of mechanisms driving protein sorting into exosomes is only beginning to emerge. In a paper recently published in Cell Research, Roucourt et al. report that trimming of heparan sulfate side chains of syndecans by endosomal heparanase facilitates sorting into exosomes by the formation of tight syndecan clusters that are recruited by the multivalent adaptor syntenin to the ALIX-ESCRT sorting machinery at endosomes.

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收藏

页码：531 / 532

页数：2

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