3,4-dihydro-1-isoquinolinamines: A novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency

被引：37

作者：

Beaton, H

Hamley, P

Nicholls, DJ

Tinker, AC

Wallace, AV

机构：

[1] AstraZeneca R&D Charnwood, Dept Med Chem, Loughborough LE11 5RH, Leics, England

[2] AstraZeneca R&D Charnwood, Dept Biosci, Loughborough LE11 5RH, Leics, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(01)00119-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

3-Phenyl-3,4-dihydro-1-isoquinolinamine is a weak inhibitor of iNOS and nNOS. Structural variation of 5a results in inhibitors with a range of potency and selectivity for the NOS enzymes, including a potent and very selective iNOS inhibitor Jj. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：1023 / 1026

页数：4

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