Synthesis of C5-substituted imidazolines

被引：9

作者：

Defacqz, N

Van, TT

Cordi, A

Marchand-Brynaert, J

机构：

[1] Univ Catholique Louvain, Unite Chim Organ & Med, B-1348 Louvain, Belgium

[2] Inst Rech Servier, F-92150 Suresnes, France

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 51期

关键词：

imidazoline; Mitsunobu reaction;

D O I：

10.1016/j.tetlet.2003.10.044

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-(Hydroxymethyl)-3-(t-butyloxycarbonyl)imidazoline 2 was prepared in four steps from 2,3-diaminopropionic acid in 72% overall yield. Mitsunobu reaction with a series of phenol derivatives gave the corresponding 5-(aryloxymethyl)-3-(t-butyloxycarbonyl)imidazolines 8a-1. Phthalimide and N-benzyl trifluoroacetamide also reacted. (C) 2003 Elsevier Ltd. All rights reserved.

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收藏

页码：9111 / 9114

页数：4

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