A stereoselective synthesis of anti-γ,δ-alkynyl- and -alkenyl-β-hydroxy-α-amino esters from tin(II) enolates of glycinate

被引：14

作者：

Gridley, JJ ^{[1
]}

Coogan, MP ^{[1
]}

Knight, DW ^{[1
]}

Malik, KMA ^{[1
]}

Sharland, CM ^{[1
]}

Singkhonrat, J ^{[1
]}

Williams, S ^{[1
]}

机构：

[1] Cardiff Univ, Dept Chem, Cardiff CF10 3TB, S Glam, Wales

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 20期

关键词：

D O I：

10.1039/b306291k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Condensations between the tin(II) enolate 11 of ethyl N-tosylglycinate and conjugated ynals 12 and ynones 14 are highly diastereoselective, in favour of the anti-isomers 13 and 15; similar reactions of enals and enones 17 show lower but still useful levels of anti-stereoselectivity.

引用

页码：2550 / 2551

页数：2

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