Altered inhibitory input to Purkinje cells of dystrophin-deficient mice

被引：42

作者：

Anderson, JL ^{[1
]}

Head, SI ^{[1
]}

Morley, JW ^{[1
]}

机构：

[1] Univ New S Wales, Sch Med Sci, Sydney, NSW 2052, Australia

来源：

BRAIN RESEARCH | 2003年 / 982卷 / 02期

关键词：

GABA(A); Purkinje cell; muscular dystrophy; mdx; dystrophin;

D O I：

10.1016/S0006-8993(03)03018-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated evoked EPSPs and spontaneous IPSPs in cerebellar slices from dystrophin-deficient mdx mice. In the presence of the GABA(A) antagonist bicuculline the increase in EPSP amplitude was less in mdx Purkinje cells compared to control, and the amplitude of miniature IPSCs in mdx cells was also significantly less than in controls. This reduced inhibitory input is most likely due to the reported reduction in the size of GABA(A), channel clusters. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：280 / 283

页数：4