Maternal Plasma P-selectin at 11 to 13 Weeks of Gestation in Hypertensive Disorders of Pregnancy

被引：15

作者：

Akolekar, Ranjit ^{[1
]}

Veduta, Alina ^{[1
]}

Minekawa, Ryoko ^{[1
]}

Chelemen, Teodora ^{[1
]}

Nicolaides, Kypros H. ^{[1
]}

机构：

[1] Kings Coll Hosp London, Harris Birthright Res Ctr Fetal Med, London SE5 9RS, England

来源：

HYPERTENSION IN PREGNANCY | 2011年 / 30卷 / 03期

关键词：

P-selectin; First trimester screening; Preeclampsia; Uterine artery Doppler; NUCHAL-TRANSLUCENCY THICKNESS; PLATELET ACTIVATION; ADHESION MOLECULES; PLACENTAL BED; PREECLAMPSIA; WOMEN; AGE; GMP-140; PROTEIN; TRISOMY-21;

D O I：

10.3109/10641950903242683

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective. To determine if development of preeclampsia is preceded by altered maternal plasma P-selectin and if the levels are related with uterine artery pulsatility index. Methods. Plasma P-selectin and uterine artery pulsatility index were measured at 11-13 weeks in 121 cases that subsequently developed preeclampsia, 87 cases that developed gestational hypertension and 208 unaffected controls. Results. In the preeclampsia group the median multiple of the median in controls (MoM) P-selectin and uterine artery PI were significantly increased (1.2 MoM and 1.3 MoM). There was no significant association between P-selectin and uterine artery pulsatility index in either the preeclampsia or control group. Conclusion. In pregnancies that develop preeclampsia there is evidence of platelet activation from the first trimester. However, there is no direct link between the degree of impaired placentation and platelet activation.

引用

页码：311 / 321

页数：11

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