Angiopoietin-2 TIEs Up Macrophages in Tumor Angiogenesis

被引：83

作者：

De Palma, Michele ^{[1
,2
]}

Naldini, Luigi ^{[1
,2
,3
]}

机构：

[1] Ist Sci San Raffaele, Angiogenesis & Tumor Targeting Unit, I-20132 Milan, Italy

[2] Ist Sci San Raffaele, San Raffaele Telethon Inst Gene Therapy, I-20132 Milan, Italy

[3] Vita Salute San Raffale Univ, Milan, Italy

来源：

CLINICAL CANCER RESEARCH | 2011年 / 17卷 / 16期

基金：

欧洲研究理事会;

关键词：

ADVANCED SOLID TUMORS; TIE2-EXPRESSING MONOCYTES; AMG; 386; EMBRYONIC ANGIOGENESIS; ANTITUMOR-ACTIVITY; ENDOTHELIAL-CELLS; VESSEL MATURATION; MAMMARY-TUMORS; MYELOID CELLS; GROWTH;

D O I：

10.1158/1078-0432.CCR-10-0171

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Angiopoietin-2 (ANG2), a ligand of the TIE2 receptor, modulates endothelial cell biology and destabilizes blood vessels to facilitate angiogenesis. Recent reports have shown that ANG2 inhibition, for example, by monoclonal antibodies, peptibodies, or CovX-Bodies, may achieve substantial antiangiogenic and antitumor responses in a variety of mouse tumor models, including spontaneous MMTV-PyMT mammary and RIP1-Tag2 pancreatic islet adenocarcinomas. There is also evidence that targeting the ANG2/TIE2 signaling pathway may inhibit the functions of TIE2-expressing macrophages (TEM), a tumor-associated macrophage subset endowed with proangiogenic activity in mouse tumor models. The clinical opportunities afforded by simultaneously targeting the effects of ANG2 on tumor angiogenesis and the proangiogenic activity of TEMs are discussed. Clin Cancer Res; 17(16); 5226-32. (C)2011 AACR.

引用

页码：5226 / 5232

页数：7

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