What are the facts and artifacts of the pathogenesis and etiology of Alzheimer disease?

被引:29
作者
Smith, MA [1 ]
Perry, G [1 ]
机构
[1] Case Western Reserve Univ, Inst Pathol, Cleveland, OH 44106 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S0891-0618(98)00061-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Over the past decade, an increased clinical awareness, together with advances in biochemical, cellular, and molecular analyses, have catapulted the study of Alzheimer disease to the forefront of biomedical research. During this time, a great number of theories, regarding disease pathogenesis, have come and gone but several have persisted. Here, we critically evaluate these theories in an attempt to delineate the facts from the artifacts. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:35 / 41
页数:7
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