Linkage disequilibrium - understanding the evolutionary past and mapping the medical future

被引：951

作者：

Slatkin, Montgomery ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA

来源：

NATURE REVIEWS GENETICS | 2008年 / 9卷 / 06期

关键词：

D O I：

10.1038/nrg2361

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Linkage disequilibrium - the nonrandom association of alleles at different loci - is a sensitive indicator of the population genetic forces that structure a genome. Because of the explosive growth of methods for assessing genetic variation at a fine scale, evolutionary biologists and human geneticists are increasingly exploiting linkage disequilibrium in order to understand past evolutionary and demographic events, to map genes that are associated with quantitative characters and inherited diseases, and to understand the joint evolution of linked sets of genes. This article introduces linkage disequilibrium, reviews the population genetic processes that affect it and describes some of its uses. At present, linkage disequilibrium is used much more extensively in the study of humans than in non-humans, but that is changing as technological advances make extensive genomic studies feasible in other species.

引用

页码：477 / 485

页数：9

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