Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

被引：647

作者：

Patil, C ^{[1
]}

Walter, P ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, Howard Hughes Med Inst, San Francisco, CA 94143 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0955-0674(00)00219-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cellular survival of endoplasmic reticulum stress requires the unfolded protein response (UPR), a stress response first elucidated genetically in yeast. While we continue to refine our knowledge of the yeast system, especially the breadth and significance of the transcriptional response, conservation of the system's elements has allowed identification of corresponding and additional components of the mammalian UPR. Recent results reveal that the output of the mammalian UPR reaches beyond transcriptional regulation of secretory pathway components to control of general translation, the cell cycle and programmed cell death.

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收藏

页码：349 / 356

页数：8

相关论文

共 53 条

[1]

Barbosa-Tessmann IP, 2000, J BIOL CHEM, V275, P26976

[2] Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response [J].

Bertolotti, A ;

Zhang, YH ;

Hendershot, LM ;

Harding, HP ;

Ron, D .

NATURE CELL BIOLOGY, 2000, 2 (06) :326-332

[3] PERK mediates cell-cycle exit during the mammalian unfolded protein response [J].

Brewer, JW ;

Diehl, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (23) :12625-12630

[4] Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression [J].

Brewer, JW ;

Hendershot, LM ;

Sherr, CJ ;

Diehl, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (15) :8505-8510

[5] ER protein quality control and proteasome-mediated protein degradation [J].

Brodsky, JL ;

McCracken, AA .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 1999, 10 (05) :507-513

[6] Degradation of proteins from the ER of S-cerevisiae requires an intact unfolded protein response pathway [J].

Casagrande, R ;

Stern, P ;

Diehn, M ;

Shamu, C ;

Osario, M ;

Zúñiga, M ;

Brown, PO ;

Ploegh, H .

MOLECULAR CELL, 2000, 5 (04) :729-735

[7] The sarco/endoplasmic reticulum calcium-ATPase 2b is an endoplasmic reticulum stress-inducible protein [J].

Caspersen, C ;

Pedersen, PS ;

Treiman, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (29) :22363-22372

[8] Translational attenuation mediated by an mRNA intron [J].

Chapman, RE ;

Walter, P .

CURRENT BIOLOGY, 1997, 7 (11) :850-859

[9] TRANSCRIPTIONAL INDUCTION OF GENES ENCODING ENDOPLASMIC-RETICULUM RESIDENT PROTEINS REQUIRES A TRANSMEMBRANE PROTEIN-KINASE [J].

COX, JS ;

SHAMU, CE ;

WALTER, P .

CELL, 1993, 73 (06) :1197-1206

[10] A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response [J].

Cox, JS ;

Walter, P .

CELL, 1996, 87 (03) :391-404

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