Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

被引：647

作者：

Patil, C ^{[1
]}

Walter, P ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, Howard Hughes Med Inst, San Francisco, CA 94143 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0955-0674(00)00219-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cellular survival of endoplasmic reticulum stress requires the unfolded protein response (UPR), a stress response first elucidated genetically in yeast. While we continue to refine our knowledge of the yeast system, especially the breadth and significance of the transcriptional response, conservation of the system's elements has allowed identification of corresponding and additional components of the mammalian UPR. Recent results reveal that the output of the mammalian UPR reaches beyond transcriptional regulation of secretory pathway components to control of general translation, the cell cycle and programmed cell death.

引用

收藏

页码：349 / 356

页数：8

相关论文

共 53 条

[31] The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complex [J].

Roy, B ;

Lee, AS .

NUCLEIC ACIDS RESEARCH, 1999, 27 (06) :1437-1443

[32] Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression [J].

Sato, N ;

Urano, F ;

Leem, JY ;

Kim, SH ;

Li, MQ ;

Donoviel, D ;

Bernstein, A ;

Lee, AS ;

Ron, D ;

Veselits, ML ;

Sisodia, SS ;

Thinakaran, G .

NATURE CELL BIOLOGY, 2000, 2 (12) :863-870

[33] The unfolded protein response represses nitrogen-starvation induced developmental differentiation in yeast [J].

Schröder, M ;

Chang, JS ;

Kaufman, RJ .

GENES & DEVELOPMENT, 2000, 14 (23) :2962-2975

[34]

Shamu Caroline E., 1994, Trends in Cell Biology, V4, P56, DOI 10.1016/0962-8924(94)90011-6

[35] Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus [J].

Shamu, CE ;

Walter, P .

EMBO JOURNAL, 1996, 15 (12) :3028-3039

[36] Identification and characterization of pancreatic eukaryotic initiation factor 2 α-subunit kinase, PEK, involved in translational control [J].

Shi, YG ;

Vattem, KM ;

Sood, R ;

An, J ;

Liang, JD ;

Stramm, L ;

Wek, RC .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (12) :7499-7509

[37] The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response [J].

Sidrauski, C ;

Walter, P .

CELL, 1997, 90 (06) :1031-1039

[38] tRNA ligase is required for regulated mRNA splicing in the unfolded protein response [J].

Sidrauski, C ;

Cox, JS ;

Walter, P .

CELL, 1996, 87 (03) :405-413

[39]

Srivastava RK, 1999, MOL CELL BIOL, V19, P5659

[40] The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response [J].

Tirasophon, W ;

Lee, K ;

Callaghan, B ;

Welihinda, A ;

Kaufman, RJ .

GENES & DEVELOPMENT, 2000, 14 (21) :2725-2736

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