The evolution of the DLK1-DIO3 imprinted domain in mammals

被引：148

作者：

Edwards, Carol A. ^{[1
]}

Mungall, Andrew J. ^{[2
]}

Matthews, Lucy ^{[2
]}

Ryder, Edward ^{[3
]}

Gray, Dionne J. ^{[1
]}

Pask, Andrew J. ^{[4
]}

Shaw, Geoffrey ^{[4
]}

Graves, Jennifer A. M. ^{[5
]}

Rogers, Jane ^{[2
]}

Dunham, Ian ^{[2
]}

Renfree, Marilyn B. ^{[4
]}

Ferguson-Smith, Anne C. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Phys Dev & Neurosci, Cambridge, England

[2] Wellcome Trust Sanger Inst, Cambridge, England

[3] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England

[4] Univ Melbourne, Dept Zool, Melbourne, Vic 3010, Australia

[5] Australian Natl Univ, Res Sch Biol Sci, Canberra, ACT 2601, Australia

来源：

PLOS BIOLOGY | 2008年 / 6卷 / 06期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1371/journal.pbio.0060135

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A comprehensive, domain-wide comparative analysis of genomic imprinting between mammals that imprint and those that do not can provide valuable information about how and why imprinting evolved. The imprinting status, DNA methylation, and genomic landscape of the Dlk1-Dio3 cluster were determined in eutherian, metatherian, and prototherian mammals including tammar wallaby and platypus. Imprinting across the whole domain evolved after the divergence of eutherian from marsupial mammals and in eutherians is under strong purifying selection. The marsupial locus at 1.6 megabases, is double that of eutherians due to the accumulation of LINE repeats. Comparative sequence analysis of the domain in seven vertebrates determined evolutionary conserved regions common to particular subgroups and to all vertebrates. The emergence of Dlk1-Dio3 imprinting in eutherians has occurred on the maternally inherited chromosome and is associated with region-specific resistance to expansion by repetitive elements and the local introduction of noncoding transcripts including microRNAs and C/D small nucleolar RNAs. A recent mammal-specific retrotransposition event led to the formation of a completely new gene only in the eutherian domain, which may have driven imprinting at the cluster.

引用

页码：1292 / 1305

页数：14

共 56 条

[51] High-resolution map and imprinting analysis of the Gtl2-Dnchc1 domain on mouse chromosome 12
Tierling, S
Dalbert, S
Schoppenhorst, S
Tsai, CE
Oliger, S
Ferguson-Smith, AC
Paulsen, M
Walter, J
[J]. GENOMICS, 2006, 87 (02) : 225 - 235
[52] Hotspots of mutation and breakage in dog and human chromosomes
Webber, C
Ponting, CP
[J]. GENOME RESEARCH, 2005, 15 (12) : 1787 - 1797
[53] Comparative phylogenetic analysis reveals multiple non-imprinted isoforms of opossum Dlk1
Weidman, JR
Maloney, KA
Jirtle, RL
[J]. MAMMALIAN GENOME, 2006, 17 (02) : 157 - 167
[54] Novel imprinted DLK11 GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF21 H19 regulation
Wylie, AA
Murphy, SK
Orton, TC
Jirtle, RL
[J]. GENOME RESEARCH, 2000, 10 (11) : 1711 - 1718
[55] Dlk1 expression marks developing endothelium and sites of branching morphogenesis in the mouse embryo and placenta
Yevtodiyenko, A
Schmidt, JV
[J]. DEVELOPMENTAL DYNAMICS, 2006, 235 (04) : 1115 - 1123
[56] A small family of sushi-class retrotransposon-derived genes in mammals and their relation to genomic imprinting
Youngson, NA
Kocialkowski, S
Peel, N
Ferguson-Smith, AC
[J]. JOURNAL OF MOLECULAR EVOLUTION, 2005, 61 (04) : 481 - 490

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