Antibacterial effects of carbon nanotubes: Size does matter

被引：879

作者：

Kang, Seoktae ^{[1
]}

Herzberg, Moshe ^{[1
]}

Rodrigues, Debora F. ^{[1
]}

Elimelech, Menachem ^{[1
]}

机构：

[1] Yale Univ, Dept Chem Engn, New Haven, CT 06520 USA

来源：

LANGMUIR | 2008年 / 24卷 / 13期

关键词：

D O I：

10.1021/la800951v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We provide the first evidence that the size (diameter) of carbon nanotubes (CNTs) is a key factor governing their antibacterial effects and that the likely main CNT-cytotoxicity mechanism is cell membrane damage by direct contact with CNTs. Experiments with well-characterized single-walled carbon nanotubes (SWNTs) and multiwalled carbon nanotubes (MWNTs) demonstrate that SWNTs are much more toxic to bacteria than MWNTs. Gene expression data show that in the presence of both MWNTs and SWNTs, Escherichia coli expresses high levels of stress-related gene products, with the quantity and magnitude of expression being much higher in the presence of SWNTs.

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收藏

页码：6409 / 6413

页数：5

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