Distinguishing features of developing natural killer cells

被引：70

作者：

Vosshenrich, CAJ ^{[1
]}

Samson-Villéger, SI ^{[1
]}

Di Santo, JP ^{[1
]}

机构：

[1] Inst Pasteur, INSERM, U668, Unite Cytokines & Dev Lymphoide, F-75724 Paris, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 2005年 / 17卷 / 02期

关键词：

D O I：

10.1016/j.coi.2005.01.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although NK cells were initially described as lymphocytes that lacked the characteristic markers of B and T cells, we now appreciate the plethora of activating and inhibitory receptors that define the NK cell surface phenotype. Recent studies have provided new insights into the molecular mechanisms that drive NK cell development, control the NK cell receptor repertoire and the cytokines that define the NK cell niche. These findings form the basis for an updated model of NK cell differentiation.

引用

页码：151 / 158

页数：8

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