Calcium Flux between the Endoplasmic Reticulum and Mitochondrion Contributes to Poliovirus-Induced Apoptosis

被引：60

作者：

Brisac, Cynthia ^{[1
,2
,3
]}

Teoule, Francois ^{[1
,2
]}

Autret, Arnaud ^{[1
,2
]}

Pelletier, Isabelle ^{[1
,2
]}

Colbere-Garapin, Florence ^{[1
,2
]}

Brenner, Catherine ^{[3
,4
]}

Lemaire, Christophe ^{[3
,4
]}

Blondel, Bruno ^{[1
,2
]}

机构：

[1] Inst Pasteur, Unite Biol Virus Enter, F-75015 Paris, France

[2] INSERM, U994, Paris, France

[3] Univ Versailles St Quentin, Versailles, France

[4] INSERM, U769, Chatenay Malabry, France

来源：

JOURNAL OF VIROLOGY | 2010年 / 84卷 / 23期

关键词：

MEMBRANE PERMEABILIZATION; CELL-DEATH; PATHWAY;

D O I：

10.1128/JVI.00994-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

We show that poliovirus (PV) infection induces an increase in cytosolic calcium (Ca2+) concentration in neuroblastoma IMR5 cells, at least partly through Ca2+ release from the endoplasmic reticulum lumen via the inositol 1,4,5-triphosphate receptor (IP3R) and ryanodine receptor (RyR) channels. This leads to Ca2+ accumulation in mitochondria through the mitochondrial Ca2+ uniporter and the voltage-dependent anion channel (VDAC). This increase in mitochondrial Ca2+ concentration in PV-infected cells leads to mitochondrial dysfunction and apoptosis.

引用

页码：12226 / 12235

页数：10

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