Broad HIV-1 neutralization mediated by CD4-binding site antibodies

被引：337

作者：

Li, Yuxing

Migueles, Stephen A.

Welcher, Brent

Svehla, Krisha

Phogat, Adhuna

Louder, Mark K.

Wu, Xueling

Shaw, George M.

Connors, Mark

Wyatt, Richard T. ^{[1
]}

Mascola, John R.

机构：

[1] Natl Inst Hlth, Vaccine Res Ctr, Bethesda, MD 20892 USA

[2] NIAID, Immunoregulat Lab, Natl Inst Hlth, Bethesda, MD 20892 USA

[3] Univ Alabama Birmingham, Dept Med & Microbiol, Birmingham, AL 35294 USA

来源：

NATURE MEDICINE | 2007年 / 13卷 / 09期

关键词：

D O I：

10.1038/nm1624

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have identified several patient sera showing potent and broad HIV-1 neutralization. Using antibody adsorption and elution from selected gp120 variants, the neutralizing specificities of the two most broadly reactive sera were mapped to the primary receptor CD4-binding region of HIV-1 gp120. Novel antibodies to the CD4-binding site are elicited in some HIV-1-infected individuals, and new approaches to present this conserved region of gp120 to the immune system may result in improved vaccine immunogens.

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页码：1032 / 1034

页数：3

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