Evaluation of a sulfobutyl ether β-cyclodextrin as a solubilizing/stabilizing agent for several drugs

To evaluate the potential use of beta-cyclodextrin sulfobutyl ether; 7 sodium salt (SBE7-beta-CD) as a drug solubilizing and stabilizing agent, the solubilizing effects of SBE7-beta-CD on 22 different poorly water-soluble drugs were compared with those of intact beta-CD and heptakis-(2,6-di-O-methyl)-beta-CD (DMCD). SBE7-beta-CD was generally a more effective solubilizer for poorly water-soluble drugs than was intact beta-CD, but SBE7-beta-CD was not as effective as DMCD. The effects of SBE7-beta-CD on the acid hydrolysis rate of prostaglandin I-2, the alkaline hydrolysis rare of indomethacin, the dehydration of prostaglandin E-1, and the isomerization of prostaglandin A(1) were also investigated and compared to those far intact beta-CD, DMCD, and 2,3,6 partially methylated-beta-CD (PMCD). The stabilizing effects of SBE7-beta-CD on chemically unstable drugs were generally higher than chose of other CDs.