A novel, base-labile fluorous amine protecting group: synthesis and use as a tag in the purification of synthetic peptides

被引：51

作者：

de Visser, PC

van Helden, M

Filippov, DV

van der Marel, GA

Drijfhout, JW

van Boom, JH

Noort, D

Overkleeft, HS

机构：

[1] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands

[2] Leiden Univ, Ctr Med, NL-2300 RC Leiden, Netherlands

[3] TNO, Prins Maurits Lab, NL-2280 AA Rijswijk, Netherlands

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 50期

关键词：

fluorous; Msc protecting group; synthetic peptides; purification;

D O I：

10.1016/j.tetlet.2003.09.220

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new, base-labile fluorous tag based on the Msc amine protecting group was synthesized. Its use in the purification of synthetic peptides by fluorous HPLC or fluorous SPE was demonstrated. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：9013 / 9016

页数：4