Homocysteine and cognitive performance: Modification by the ApoE genotype

被引：41

作者：

Elias, Merrill F. ^{[1
]}

Robbins, Michael A. ^{[1
]}

Budge, Marc M. ^{[2
]}

Elias, Penelope K. ^{[1
]}

Dore, Gregory A. ^{[1
]}

Brennan, Suzanne L. ^{[1
]}

Johnston, Carole ^{[3
]}

Nagy, Zsuzsanna ^{[4
]}

机构：

[1] Univ Maine, Dept Psychol, Orono, ME 04469 USA

[2] Australian Natl Univ, Canberra Hosp, Dept Geriatr Med, Woden, ACT 2605, Australia

[3] Univ Oxford, Dept Physiol Anat & Genet, OPTIMA, Oxford OX1 3PT, England

[4] Univ Birmingham, Sch Med, Div Neurosci, Birmingham B15 2TT, W Midlands, England

来源：

NEUROSCIENCE LETTERS | 2008年 / 430卷 / 01期

关键词：

ApoE; homocysteine; cardiovascular risk factors; vitamins; cognitive performance;

D O I：

10.1016/j.neulet.2007.10.021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We hypothesized that the magnitude of the association between plasma homocysteine concentration and cognitive performance is larger for ApoE-epsilon 4 carriers than for non-carriers. Nine hundred eleven dementia-free and stroke-free subjects (59% women) from the Maine-Syracuse study (26-98 years old) were stratified into no-ApoE-epsilon 4 (n = 667) and ApoE-epsilon 4 carrier (n = 244) cohorts. Employing a cross-sectional design and multiple regression analyses, plasma homocysteine was related to multiple domains of cognitive performance within these cohorts. When unadjusted, and with adjustment for age, education, gender, ethnicity, and previous cognitive examinations, homocysteine concentrations were inversely related to cognitive performance within both ApoE cohorts, with higher magnitude of associations within the ApoE-epsilon 4 cohort. With adjustment for cardiovascular disease risk factors, cardiovascular disease, and B-vitamin concentrations, the higher magnitude of associations between plasma homocysteine and cognitive performance within the ApoE-epsilon 4 cohort relative to the no-ApoE-epsilon 4 cohort persisted; but associations of plasma homocysteine and cognitive performance were attenuated and no longer significant within the no-ApoE-epsilon 4 cohort. Presence of the ApoE-epsilon 4 allele modifies the relation between plasma homocysteine and cognitive performance. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：64 / 69

页数：6

共 48 条

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