Overview of the status and applications of capillary electrophoresis to the analysis of small molecules

被引:109
作者
Altria, KD
Elder, D
机构
[1] GlaxoSmithKline Res & Dev Ltd, Pharmaceut Dev, Prod Line Extens Dept, Harlow CM19 5AW, Essex, England
[2] GlaxoSmithKline Res & Dev Ltd, Pharmaceut Dev, New Chem Ent Dept, Ware SG12 0DP, Herts, England
关键词
reviews; capillary electrophoresis; small molecules;
D O I
10.1016/j.chroma.2003.10.054
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The status of capillary electrophoresis (CE) in the analysis of small molecules is reviewed and summarised with the illustrative use of recent literature references. Examples are cited in this review which demonstrate that CE is now a recognised and established technique in many industries, law courts and government regulatory agencies. Each of the principal areas of CE application in small molecule analysis are covered in sections which highlight the recent developments and possibilities within that area. Application areas include the analysis of pharmaceuticals, agrochemicals, chiral separations, and forensics is covered. This is an update to a previous review article [J. Chromatogr. A 856 (1999) 443] and covers papers published between 1999 and 2002. Technical developments and improvements, such as the advent of capillary array instrumentation for increased sample throughput, and improved detection options are described. Overall it is concluded that CE has become a recognised and established technique in many areas and is still within a period of development of both instrumentation and application which will continue to expand usage. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码:1 / 14
页数:14
相关论文
共 131 条
[41]   Characterization and analysis of biphalin: an opioid peptide with a palindromic sequence [J].
Hettiarachchi, K ;
Ridge, S ;
Thomas, DW ;
Olson, L ;
Obi, CR ;
Singh, D .
JOURNAL OF PEPTIDE RESEARCH, 2001, 57 (02) :151-161
[42]   Optimization and validation of a capillary zone electrophoretic method for the analysis of several angiotensin-II-receptor antagonists [J].
Hillaert, S ;
Van den Bossche, W .
JOURNAL OF CHROMATOGRAPHY A, 2002, 979 (1-2) :323-333
[43]  
Holland LA, 2002, ELECTROPHORESIS, V23, P3649, DOI 10.1002/1522-2683(200211)23:21<3649::AID-ELPS3649>3.0.CO
[44]  
2-O
[45]   Analytical separation techniques for the determination of chemical warfare agents [J].
Hooijschuur, EWJ ;
Kientz, CE ;
Brinkman, UAT .
JOURNAL OF CHROMATOGRAPHY A, 2002, 982 (02) :177-200
[46]   Thirty-five years of capillary electrophoresis: Advances and perspectives [J].
Issaq, HJ .
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2002, 25 (08) :1153-1170
[47]  
JIMIDAR M, 2002, LC GC APR, P230
[48]   Capillary electrophoresis-inductively coupled plasma-mass spectrometry: an attractive complementary technique for elemental speciation analysis [J].
Kannamkumarath, SS ;
Wrobel, K ;
Wrobel, K ;
B'Hymer, C ;
Caruso, JA .
JOURNAL OF CHROMATOGRAPHY A, 2002, 975 (02) :245-266
[49]   An integrated process for measuring the physicochemical properties of drug candidates in a preclinical discovery environment [J].
Kibbey, CE ;
Poole, SK ;
Robinson, B ;
Jackson, JD ;
Durham, D .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2001, 90 (08) :1164-1175
[50]  
Klampfl CW, 2001, ELECTROPHORESIS, V22, P2737, DOI 10.1002/1522-2683(200108)22:13&lt