Fumarate Esters as Angiogenesis Inhibitors: Key to Action in Psoriasis?

被引：20

作者：

Arbiser, Jack L. ^{[1
,2
,3
]}

机构：

[1] Emory Univ, Sch Med, Dept Dermatol, Atlanta, GA 30322 USA

[2] Atlanta Vet Adm Med Ctr, Atlanta, GA USA

[3] Winship Canc Inst, Atlanta, GA USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2011年 / 131卷 / 06期

关键词：

LEIOMYOMATA; MUTATIONS;

D O I：

10.1038/jid.2011.45

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Fumarate esters-an oral therapy for psoriasis-are used primarily in Europe, but not at all in the United States. Given that biological therapies are exceedingly expensive and pose an increased risk for infections and malignancy, the need for safer and less expensive therapies for psoriasis is compelling. Nonbiological therapies for psoriasis, including methotrexate and systemic retinoids, carry potentially severe side effects and relatively high cost. Fumarate, a natural product that is generated internally in humans during the Krebs cycle, is an attractive alternative to these therapies. However, the mechanism for fumarate's activity in psoriasis remains unknown.

引用

页码：1189 / 1191

页数：3

共 11 条

[1] Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice [J].

Belcher, JD ;

Mahaseth, H ;

Welch, TE ;

Otterbein, LE ;

Hebbel, RP ;

Vercellotti, GM .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (03) :808-816

[2] Hypoxia-inducible factor 1α stabilization by carbon monoxide results in cytoprotective preconditioning [J].

Chin, Beek Y. ;

Jiang, Ge ;

Wegiel, Barbara ;

Wang, Hong J. ;

MacDonald, Theresa ;

Zhang, Xu Chen ;

Gallo, David ;

Cszimadia, Eva ;

Bach, Fritz H. ;

Lee, Patty J. ;

Otterbein, Leo E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (12) :5109-5114

[3] Cancer-associated IDH1 mutations produce 2-hydroxyglutarate (vol 462, pg 739, 2010) [J].

Dang, Lenny ;

White, David W. ;

Gross, Stefan ;

Bennett, Bryson D. ;

Bittinger, Mark A. ;

Driggers, Edward M. ;

Fantin, Valeria R. ;

Jang, Hyun Gyung ;

Jin, Shengfang ;

Keenan, Marie C. ;

Marks, Kevin M. ;

Prins, Robert M. ;

Ward, Patrick S. ;

Yen, Katharine E. ;

Liau, Linda M. ;

Rabinowitz, Joshua D. ;

Cantley, Lewis C. ;

Thompson, Craig B. ;

Vander Heiden, Matthew G. ;

Su, Shinsan M. .

NATURE, 2010, 465 (7300) :966-966

[4] Dimethylfumarate Inhibits Angiogenesis In Vitro and In Vivo: A Possible Role for Its Antipsoriatic Effect? [J].

Garcia-Caballero, Melissa ;

Mari-Beffa, Manuel ;

Medina, Miguel A. ;

Quesada, Ana R. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 (06) :1347-1355

[5] HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma [J].

Gordan, John D. ;

Lal, Priti ;

Dondeti, Vijay R. ;

Letrero, Richard ;

Parekh, Krishna N. ;

Oquendo, C. Elisa ;

Greenberg, Roger A. ;

Flaherty, Keith T. ;

Rathmell, W. Kimryn ;

Keith, Brian ;

Simon, M. Celeste ;

Nathanson, Katherine L. .

CANCER CELL, 2008, 14 (06) :435-446

[6] Cell-permeating α-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells [J].

MacKenzie, Elaine D. ;

Selak, Mary A. ;

Tennant, Daniel A. ;

Payne, Lloyd J. ;

Crosby, Stuart ;

Frederiksen, Casper M. ;

Watson, David G. ;

Gottlieb, Eyal .

MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (09) :3282-3289

[7] Germline fumarate hydratase mutations in families with multiple cutaneous and uterine leiomyomata [J].

Martinez-Mir, A ;

Glaser, B ;

Chuang, GS ;

Horev, L ;

Waldman, A ;

Engler, DE ;

Gordon, D ;

Spelman, LJ ;

Hatzibougias, I ;

Green, J ;

Christiano, AM ;

Zlotogorski, A .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2003, 121 (04) :741-744

[8] Suppression of VEGFR2 Expression in Human Endothelial Cells by Dimethylfumarate Treatment: Evidence for Anti-Angiogenic Action [J].

Meissner, Markus ;

Doll, Monika ;

Hrgovic, Igor ;

Reichenbach, Gabi ;

Koenig, Veronika ;

Hailemariam-Jahn, Tsige ;

Gille, Jens ;

Kaufmann, Roland .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 (06) :1356-1364

[9] Targeted inactivation of Fh1 causes proliferative renal cyst development and activation of the hypoxia pathway [J].

Pollard, Patrick J. ;

Spencer-Dene, Bradley ;

Shukla, Deepa ;

Howarth, Kimberley ;

Nye, Emma ;

El-Bahrawy, Mona ;

Deheragoda, Maesha ;

Joannou, Maria ;

McDonald, Stuart ;

Martin, Alison ;

Igarashi, Peter ;

Varsani-Brown, Sunita ;

Rosewell, Ian ;

Poulsom, Richard ;

Maxwell, Patrick ;

Stamp, Gordon W. ;

Tomlinson, Ian P. M. .

CANCER CELL, 2007, 11 (04) :311-319

[10] Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer [J].

Tomlinson, IPM ;

Alam, NA ;

Rowan, AJ ;

Barclay, E ;

Jaeger, EEM ;

Kelsell, D ;

Leigh, I ;

Gorman, P ;

Lamlum, H ;

Rahman, S ;

Roylance, RR ;

Olpin, S ;

Bevan, S ;

Barker, K ;

Hearle, N ;

Houlston, RS ;

Kiuru, M ;

Lehtonen, R ;

Karhu, A ;

Vilkki, S ;

Laiho, P ;

Eklund, C ;

Vierimaa, O ;

Aittomäki, K ;

Hietala, M ;

Sistonen, P ;

Paetau, A ;

Salovaara, R ;

Herva, R ;

Launonen, V ;

Aaltonen, LA .

NATURE GENETICS, 2002, 30 (04) :406-410

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