Studies on the Biginelli reaction:: a mild and selective route to 3,4-dihydropyrimidin-2(1H)-ones via enamine intermediates

被引：102

作者：

Mabry, J ^{[1
]}

Ganem, B ^{[1
]}

机构：

[1] Cornell Univ, Baker Lab, Dept Chem & Biol Chem, Ithaca, NY 14853 USA

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Biginelli; enamines; dihydropyrimidinones;

D O I：

10.1016/j.tetlet.2005.10.124

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

L-Proline methyl ester hydrochloride was found to be an effective catalyst for assembling (+/-)-dihydropyrimidinones under mild conditions. Mechanistic insights into the useful selectivity elements of this amine-catalyzed process are also reported. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：55 / 56

页数：2

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