Dendrimer-drug interactions

被引：432

作者：

D'Emanuele, A ^{[1
]}

Attwood, D ^{[1
]}

机构：

[1] Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester M13 9PL, Lancs, England

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2005年 / 57卷 / 15期

关键词：

dendrimers; encapsulation; solubility enhancement; PEGylation; electrostatic interaction; conjugation; block copolymers;

D O I：

10.1016/j.addr.2005.09.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The interaction between drugs and dendrimers is reviewed with particular reference to the entrapment of drugs within the dendrimer architecture and the electrostatic and covalent complexation of drugs to the dendrimer surface. The application of dendrimer-drug complexation in the enhancement of drug solubility and bioavailability and the use of the complexes as vehicles for the controlled release of drugs and drug targeting is discussed. (c) 2005 Elsevier B.V. All rights reserved.

引用

收藏

页码：2147 / 2162

页数：16

相关论文

共 97 条

[31] UNIMOLECULAR MICELLES AND GLOBULAR AMPHIPHILES - DENDRITIC MACROMOLECULES AS NOVEL RECYCLABLE SOLUBILIZATION AGENTS [J].

HAWKER, CJ ;

WOOLEY, KL ;

FRECHET, JMJ .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1993, (12) :1287-1297

[32] Polyester dendritic systems for drug delivery applications:: Design, synthesis, and characterization [J].

Ihre, HR ;

De Jesüs, OLP ;

Szoka, FC ;

Fréchet, JMJ .

BIOCONJUGATE CHEMISTRY, 2002, 13 (03) :443-452

[33] Bengal rose@dendritic box [J].

Jansen, JFGA ;

Meijer, EW ;

deBrabandervandenBerg, EMM .

MACROMOLECULAR SYMPOSIA, 1996, 102 :27-33

[34] ENCAPSULATION OF GUEST MOLECULES INTO A DENDRITIC BOX [J].

JANSEN, JFGA ;

DEBRABANDERVANDENBERG, EMM ;

MEIJER, EW .

SCIENCE, 1994, 266 (5188) :1226-1229

[35] THE DENDRITIC BOX - SHAPE-SELECTIVE LIBERATION OF ENCAPSULATED GUESTS [J].

JANSEN, JFGA ;

MEIJER, EW ;

DEBRABANDERVANDENBERG, EMM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (15) :4417-4418

[36] Transport of dendrimer nanocarriers through epithelial cells via the transcellular route [J].

Jevprasesphant, R ;

Penny, J ;

Attwood, D ;

D'Emanuele, A .

JOURNAL OF CONTROLLED RELEASE, 2004, 97 (02) :259-267

[37] Engineering of dendrimer surfaces to enhance transepithelial transport and reduce cytotoxicity [J].

Jevprasesphant, R ;

Penny, J ;

Attwood, D ;

McKeown, NB ;

D'Emanuele, A .

PHARMACEUTICAL RESEARCH, 2003, 20 (10) :1543-1550

[38] The influence of surface modification on the cytotoxicity of PAMAM dendrimers [J].

Jevprasesphant, R ;

Penny, J ;

Jalal, R ;

Attwood, D ;

McKeown, NB ;

D'Emanuele, A .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2003, 252 (1-2) :263-266

[39] Polyelectrolyte behavior of astramol poly(propyleneimine) dendrimers [J].

Kabanov, VA ;

Zezin, AB ;

Rogacheva, VB ;

Gulyaeva, ZG ;

Zansochova, MF ;

Joosten, JGH ;

Brackman, J .

MACROMOLECULES, 1998, 31 (15) :5142-5144

[40] Interaction of Astramol poly(propyleneimine) dendrimers with linear polyanions [J].

Kabanov, VA ;

Zezin, AB ;

Rogacheva, VB ;

Gulyaeva, ZG ;

Zansochova, MF ;

Joosten, JGH ;

Brackman, J .

MACROMOLECULES, 1999, 32 (06) :1904-1909

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