Principles of therapeutic liver repopulation

被引：80

作者：

Grompe, M

Laconi, E

Shafritz, DA

机构：

[1] Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Portland, OR 97201 USA

[2] Univ Cagliari, Ist Patol Sperimentale, Cagliari, Italy

[3] Osped Oncol A Businco, Cagliari, Italy

[4] Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA

[5] Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10467 USA

[6] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA

[7] Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Bronx, NY 10467 USA

来源：

SEMINARS IN LIVER DISEASE | 1999年 / 19卷 / 01期

关键词：

hepatocyte transplantation; liver repopulation; gene therapy; liver stem cell;

D O I：

10.1055/s-2007-1007093

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Recently, it has been shown in several animal models that more than 90% of host hepatocytes can be replaced by a small number of transplanted donor cells in a process Ive term therapeutic liver repopulation. This phenomenon is analogous to repopulation of the hematopoietic system after bone marrow transplantation. Liver repopulation occurs when transplanted cells have a growth advantage in the setting of damage to recipient liver cells. Here we review the current knowledge of this process and discuss the hopeful implications for treatment of liver diseases.

引用

页码：7 / 14

页数：8

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[11] LOSS OF FUMARYLACETOACETATE HYDROLASE IS RESPONSIBLE FOR THE NEONATAL HEPATIC-DYSFUNCTION PHENOTYPE OF LETHAL ALBINO MICE [J].