COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome

被引：576

作者：

Hirano, Toshio ^{[1
,2
,3
]}

Murakami, Masaaki ^{[2
,3
]}

机构：

[1] Natl Inst Quantum & Radiol Sci & Technol, Chiba 2638555, Japan

[2] Hokkaido Univ, Inst Med Genet, Div Mol Psychoimmunol, Sapporo, Hokkaido 0600815, Japan

[3] Hokkaido Univ, Grad Sch Med, Sapporo, Hokkaido 0600815, Japan

来源：

IMMUNITY | 2020年 / 52卷 / 05期

关键词：

ANGIOTENSIN-CONVERTING ENZYME-2; SARS; INSIGHTS; ACE2;

D O I：

10.1016/j.immuni.2020.04.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Zhou et al. (Nature) and Hoffmann et al. (Cell) identify ACE2 as a SARS-CoV-2 receptor, and the latter show its entry mechanism depends on cellular serine protease TMPRSS2. These results may explain proinflammatory cytokine release via the associated angiotestin II pathway and a possible therapeutic target via the IL-6-STAT3 axis.

引用

页码：731 / 733

页数：4

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