A Concise Total Synthesis of (±)-Minfiensine

被引：43

作者：

Liu, Peijun

Wang, Juan

Zhang, Jiancun ^{[1
]}

Qiu, Fayang G.

机构：

[1] Chinese Acad Sci, Lab Mol Engn, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 24期

基金：

中国国家自然科学基金;

关键词：

PALLADIUM-CATALYZED CYCLIZATION; VINYL HALIDES; ALKALOIDS; PROTOCOL; SKELETON;

D O I：

10.1021/ol2027224

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise total synthesis of (+/-)-minfiensine using all conventional methods and starting from commercial materials has been completed. The synthesis features a Fischer indole synthesis, a Heck alkylation of an intermediate ketone enolate, conversion of a ketone carbonyl into an epoxide, and transformation of the latter into an allylic alcohol.

引用

收藏

页码：6426 / 6428

页数：3

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