Inhibitors of antibiotic efflux in resistant Enterobacter aerogenes and Klebsiella pneumoniae strains

被引：71

作者：

Chevalier, J

Bredin, J

Mahamoud, A

Malléa, M

Barbe, J

Pagès, JM

机构：

[1] Univ Mediterranee, Fac Med, EA2197, F-13385 Marseille 5, France

[2] Univ Mediterranee, Fac Pharm, GERCTOP, CNRS,UMR6009, F-13385 Marseille 5, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 03期

关键词：

D O I：

10.1128/AAC.48.3.1043-1046.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In Enterobacter aerogenes and Klebsiella pneumoniae, efflux provides efficient extrusion of antibiotics and contributes to the multidrug resistance phenotype. One of the alkoxyquinoline derivatives studied here, 2,8-dimethyl-4-(2'-pyrrolidinoethyl)-oxyquinoline, restores noticeable drug susceptibility to resistant clinical strains. Analyses of energy-dependent chloramphenicol efflux indicate that this compound inhibits the efflux pump mechanism and improves the activity of structurally unrelated antibiotics on multidrug-resistant E. aerogenes and K. pneumoniae isolates.

引用

收藏

页码：1043 / 1046

页数：4

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