Inhibitory effect of arphamenine A on intestinal dipeptide transport

被引：20

作者：

Enjoh, M

Hashimoto, K

Arai, S

Shimizu, M

机构：

[1] UNIV TOKYO, GRAD SCH AGR & LIFE SCI, DEPT APPL BIOL CHEM, TOKYO 113, JAPAN

[2] UNIV SHIZUOKA, DEPT FOOD SCI, SHIZUOKA 422, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1996年 / 60卷 / 11期

关键词：

dipeptide; peptide transport; Caco-2; intestinal epithelial cell;

D O I：

10.1271/bbb.60.1893

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Arphamenine A, an Arg-Phe analog without a peptide bond, has been reported to be a possible inhibitor of the peptide transporter [H. Daniel and S. A. Adibi, FASEB J., 8, 753 (1994)]. The present study demonstrates that arphamenine A is not a real inhibitor, but is a substrate for the transporter, being transported transepithelially under a proton gradient. The substrate specificity of the peptide transporter was wider than expected.

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收藏

页码：1893 / 1895

页数：3

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