Subcellular targeting analysis of SDR-type hydroxysteroid dehydrogenases

被引：9

作者：

Filling, C ^{[1
]}

Wu, XQ ^{[1
]}

Shafqat, N ^{[1
]}

Hult, M ^{[1
]}

Mårtensson, E ^{[1
]}

Shafqat, J ^{[1
]}

Oppermann, UCT ^{[1
]}

机构：

[1] Karolinska Inst, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2001年 / 171卷 / 1-2期

关键词：

short-chain dehydrogenases/reductases; aldo-keto reductases; hydroxysteroid dehydrogenase; subcellular localization; ERAB;

D O I：

10.1016/S0303-7207(00)00419-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Most mammalian hydroxysteroid dehydrogenases known thus far belong to the protein superfamilies of short-chain dehydrogenases/reductases (SDR) and aldo-keto reductases (AKR). Whereas members of the AKR family are soluble, cytoplasmic enzymes, SDR-type hydroxysteroid dehydrogenases are also located to other subcellular compartments, i.e. endoplasmic reticulum, mitochondria or peroxisomes. Differential localization might play an important role in influencing the reaction direction of hydroxy dehydrogenase/oxo reductase pathways by determining the available nucleotide cofactor pool. Targeting signals for different subcellular organelles in human hydroxysteroid dehydrogenases have been identified, however, in several enzymes localization signals remain to be determined. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：99 / 101

页数：3

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