The Present and the Future of Neuroimaging in Amyotrophic Lateral Sclerosis

被引：95

作者：

Agosta, F.

Chio, A. ^{[3
]}

Cosottini, M. ^{[4
]}

De Stefano, N. ^{[5
]}

Falini, A. ^{[2
]}

Mascalchi, M. ^{[6
]}

Rocca, M. A.

Silani, V. ^{[7
,8
]}

Tedeschi, G. ^{[9
,10
]}

Filippi, M. ^{[1
,11
]}

机构：

[1] Inst Sci, Neuroimaging Res Unit, Div Neurosci, Inst Expt Neurol, I-20132 Milan, Italy

[2] Inst Sci, Div Neurosci, Neuroradiol Unit, I-20132 Milan, Italy

[3] Univ Turin, Dept Neurosci, Turin, Italy

[4] Univ Pisa, Neuroradiol Unit, Dept Neurosci, Pisa, Italy

[5] Univ Siena, Dept Neurol & Behav Sci, I-53100 Siena, Italy

[6] Univ Florence, Dept Clin Physiopathol, Radiodiagnost Sect, Florence, Italy

[7] Univ Milan, IRCCS Ist Auxol Italiano, Dino Ferrari Ctr, Dept Neurol, Milan, Italy

[8] Univ Milan, IRCCS Ist Auxol Italiano, Dino Ferrari Ctr, Neurosci Lab, Milan, Italy

[9] Univ Naples 2, Dept Neurol Sci, Naples, Italy

[10] Inst Hermitage Capodimonte, Naples, Italy

[11] Univ Hosp San Raffaele, I-20132 Milan, Italy

来源：

AMERICAN JOURNAL OF NEURORADIOLOGY | 2010年 / 31卷 / 10期

关键词：

MAGNETIC-RESONANCE-SPECTROSCOPY; DIFFUSION TENSOR MRI; MOTOR-NEURON DISEASE; VOXEL-BASED MORPHOMETRY; FRONTOTEMPORAL LOBAR DEGENERATION; CORTICOSPINAL TRACT INVOLVEMENT; BRAIN ATROPHY; FRONTAL-LOBE; N-ACETYLASPARTATE; PRECENTRAL GYRUS;

D O I：

10.3174/ajnr.A2043

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

In patients with ALS, conventional MR imaging is frequently noninformative, and its use has been restricted to excluding other conditions that can mimic ALS. Conversely, the extensive application of modern MR imaging-based techniques to the study of ALS has undoubtedly improved our understanding of disease pathophysiology and is likely to have a role in the identification of potential biomarkers of disease progression. This review summarizes how new MR imaging technology is changing dramatically our understanding of the factors associated with ALS evolution and highlights the reasons why it should be used more extensively in studies of disease progression, including clinical trials.

引用

页码：1769 / 1777

页数：9

共 110 条

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Degeneration of the pyramidal tracts in patients with amyotrophic lateral sclerosis - A premortem and postmortem magnetic resonance imaging study [J].