WNKs: protein kinases with a unique kinase domain

被引：44

作者：

Huang, Chou-Long ^{[1
]}

Cha, Seung-Kuy

Wang, Hao-Ran

Xie, Jian

Cobb, Melanie H.

机构：

[1] Univ Texas, SW Med Ctr, Dept Med, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75390 USA

来源：

EXPERIMENTAL AND MOLECULAR MEDICINE | 2007年 / 39卷 / 05期

关键词：

genome; human; hyperkalemia; hypertension; neoplasms; protein kinases; pseudohypoaldosteronisms; WNK1; protein;

D O I：

10.1038/emm.2007.62

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in regulating ion transport were first revealed by the findings that mutations of two members cause a genetic hypertension and hyper-kalemia syndrome. More recent studies suggest that WNKs are pleiotropic protein kinases with important roles in many cell processes in addition to ion transport. Here, we review roles of WNK kinases in the regulation of ion balance, cell signaling, survival, and proliferation, and embryonic organ development.

引用

页码：565 / 573

页数：9

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