Chemistry of bis-spiroacetal systems: Natural products, synthesis and stereochemistry

被引:70
作者
Brimble, MA [1 ]
Furkert, DP [1 ]
机构
[1] Univ Auckland, Dept Chem, Auckland 1, New Zealand
关键词
D O I
10.2174/1385272033486404
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
In recent years a number of compounds containing bis-spiroacetal systems have been isolated from nature. Predominantly of dinoflagellate origin, they have stimulated much synthetic interest due to their potent biological activity and synthetically challenging structural features. Although the chemistry of bicyclic spiroacetals is well understood, that of the tricyclic bis-spiroacetals has been less fully explored. This review describes the strategies employed to construct bis-spiroacetals with particular reference to stereochemical issues associated with the quaternary spirocentres.
引用
收藏
页码:1461 / 1484
页数:24
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