Questions on viral population biology to complete dengue puzzle

被引：23

作者：

Chevillon, C

Failloux, AB

机构：

[1] CEPM, UMR CNRS IRD 9926, F-34394 Montpellier 5, France

[2] Inst Pasteur, F-75724 Paris, France

来源：

TRENDS IN MICROBIOLOGY | 2003年 / 11卷 / 09期

关键词：

D O I：

10.1016/S0966-842X(03)00206-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanisms driving the current evolution of dengue remain unclear. We argue that disregarding the population biology of viruses has been a limiting factor, and present a hypothetical framework based on viral population biology. This allows us to pinpoint three flaws that need to be addressed: (1) a large underestimation of the viral polymorphism within populations; (2) a disregard of viral loci other than that encoding the antigenic envelope; and (3) the neglect of host-driven selection, especially that of vector-driven selection.

引用

页码：415 / 421

页数：7

共 55 条

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Alvarez M, 2001, Int J Infect Dis, V5, P35, DOI 10.1016/S1201-9712(01)90046-3

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