MAP kinases in inflammatory bowel disease

被引：152

作者：

Coskun, Mehmet ^{[1
,2
]}

Olsen, Jorgen ^{[2
]}

Seidelin, Jakob Benedict ^{[1
]}

Nielsen, Ole Haagen ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Gastroenterol, Med Sect, Herlev Hosp, DK-2730 Herlev, Denmark

[2] Univ Copenhagen, Dept Cellular & Mol Med, Panum Inst, DK-2730 Herlev, Denmark

来源：

CLINICA CHIMICA ACTA | 2011年 / 412卷 / 7-8期

关键词：

Inflammation; Inflammatory bowel disease; MAP kinase; Therapy; Transcription factors; MITOGEN-ACTIVATED PROTEIN; NF-KAPPA-B; STRESS-INDUCED PHOSPHORYLATION; SIGNAL-REGULATED KINASE; INTESTINAL EPITHELIAL-CELL; TRANSCRIPTIONAL ACTIVATION; ULCERATIVE-COLITIS; TRANSDUCTION PATHWAYS; CYTOKINE PRODUCTION; REPAIR MECHANISMS;

D O I：

10.1016/j.cca.2010.12.020

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

The mammalian family of mitogen-activated protein kinases (MAPKs) is activated by diverse extracellular and intracellular stimuli, and thereby they play an essential role in connecting cell-surface receptors to changes in transcriptional programs. The MAPK signaling pathways regulate a wide range of cellular activities and have been implicated in the pathogenesis of several diseases, including inflammatory bowel disease (IBD). This review summarizes recent findings on the regulatory mechanism of MAPK signaling pathways, focusing on nuclear targets and their role in IBD. Finally, it summarizes how these signaling pathways have been exploited for the development of therapeutics and discuss the current knowledge of potential MAPK inhibitors and their anti-inflammatory effects in clinical trials related to IBD. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：513 / 520

页数：8

共 154 条

[1]

c-Jun-NH2 kinase (JNK) contributes to the regulation of c-Myc protein stability [J].