Mitogen activated protein kinases: a role in inflammatory bowel disease?

被引：190

作者：

Broom, O. J. ^{[1
]}

Widjaya, B. ^{[1
]}

Troelsen, J. ^{[2
]}

Olsen, J. ^{[2
]}

Nielsen, O. H. ^{[1
]}

机构：

[1] Univ Copenhagen, Herlev Hosp, Med Sect, Dept Gastroenterol, DK-2200 Copenhagen, Denmark

[2] Univ Copenhagen, Panum Inst, Inst Cellular & Mol Med, DK-2200 Copenhagen, Denmark

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2009年 / 158卷 / 03期

关键词：

inflammation; inflammatory bowel disease; MAP kinase; N-TERMINAL KINASE; GENOME-WIDE ASSOCIATION; FACTOR-KAPPA-B; C-JUN; MAP KINASE; CELL DIFFERENTIATION; CROHNS-DISEASE; P38; MAPK; INHIBITION; EXPRESSION;

D O I：

10.1111/j.1365-2249.2009.04033.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Since their discovery more than 15 years ago, the mitogen activated protein kinases (MAPK) have been implicated in an ever-increasingly diverse array of pathways, including inflammatory signalling cascades. Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are characterized by the perpetual production of inflammatory mediators. Research into the transduction pathway behind this over-production has highlighted the potential mediating role for the MAPKs and their related signalling components. This review highlights some of the research into the role for the MAPKs and their related signalling proteins in influencing the progression of IBD.

引用

页码：272 / 280

页数：9

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