cDNA cloning and tissue-specific splicing variants of mouse hippostasin/TLSP (PRSS20)

被引：17

作者：

Mitsui, S

Okui, A

Kominami, K

Uemura, H

Yamaguchi, N ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Res Inst Neurol Dis & Geriatr, Dept Cell Biol, Kyoto 6028566, Japan

[2] Fuso Pharmaceut Ind Ltd, Ctr Res & Dev, Joto Ku, Osaka 5368523, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2000年 / 1494卷 / 1-2期

关键词：

brain; kallikrein; serine protease; alternative splicing;

D O I：

10.1016/S0167-4781(00)00206-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two splicing variants of mouse hippostasin/TLSP,(PRSS20) were identified and termed brain-type and prostate-type, respectively. Mouse hippostasin/TLSP showed 76.8% identity to the human homologue. Transient expression showed that both translational products were secreted into the conditioned medium. Mouse hippostasin/TLSP was expressed preferentially in the fetal brain and the prostate, but not in the neonatal brain. The brain expressed only brain-type hippostasin/TLSP, while the prostate expressed both types. (C) 2000 Elsevier Science B.V. All rights reserved.

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收藏

页码：206 / 210

页数：5

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