Prognostic significance and mechanism of Treg infiltration in human brain tumors

被引：170

作者：

Jacobs, Joannes F. M. ^{[1
,2
,3
]}

Idema, Albert J. ^{[4
]}

Bol, Kalijn F. ^{[1
]}

Grotenhuis, J. Andre ^{[4
]}

de Vries, I. Jolanda M. ^{[1
,3
]}

Wesseling, Pieter ^{[5
,6
]}

Adema, Gosse J. ^{[1
]}

机构：

[1] Nijmegen Ctr Mol Life Sci, Dept Tumor Immunol, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Lab Med Immunol, NL-6525 ED Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Med Oncol, NL-6525 ED Nijmegen, Netherlands

[4] Radboud Univ Nijmegen, Med Ctr, Dept Neurosurg, NL-6525 ED Nijmegen, Netherlands

[5] Radboud Univ Nijmegen, Med Ctr, Dept Pathol, NL-6525 ED Nijmegen, Netherlands

[6] Canisius Willielmina Hosp, Dept Pathol, Nijmegen, Netherlands

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2010年 / 225卷 / 1-2期

关键词：

Glioblastoma; Regulatory T cell; Prognosis; CCR4; CCL22; Human; REGULATORY T-CELLS; ANTITUMOR IMMUNE-RESPONSES; MALIGNANT GLIOMA; RECEPTOR EXPRESSION; CD127; EXPRESSION; MURINE GLIOMA; IMMUNOTHERAPY; VACCINATION; GLIOBLASTOMA; SURVIVAL;

D O I：

10.1016/j.jneuroim.2010.05.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T cells (Tregs) accumulate in tumors and can contribute to the dismal immune responses observed in these tumors. We reported that the percentage of tumor infiltrating Tregs is strongly correlated with the WHO grade of the brain tumor. We now report on the clinical follow-up of this patient cohort (n = 83). Subgroup analyses in patients with glioblastomas (n = 29) showed a moderate, not significant, inverted association between Tregs and survival. We further show that Tregs in glioblastomas, in contrast to other tumor infiltrating effector lymphocytes, highly express the CCR4 chemokine receptor. Moreover, the CCR4 ligand CCL22 is secreted by glioblastomas and may explain the specific Treg accumulation seen in these tumors. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：195 / 199

页数：5

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