Viral Evolution and Escape during Acute HIV-1 Infection

被引：71

作者：

Boutwell, Christian L. ^{[1
]}

Rolland, Morgane M. ^{[2
,3
]}

Herbeck, Joshua T. ^{[2
,3
]}

Mullins, James I. ^{[2
,3
]}

Allen, Todd M. ^{[1
]}

机构：

[1] Ragon Inst MGH MIT & Harvard, Boston, MA USA

[2] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA

[3] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 202卷

基金：

美国国家卫生研究院;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; T-LYMPHOCYTE ESCAPE; REPLICATION CAPACITY; ELITE CONTROLLERS; VACCINE DESIGN; CTL ESCAPE; TRANSMISSION; MUTATIONS; VARIANTS; EPITOPES;

D O I：

10.1086/655653

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The extensive genetic diversity of human immunodeficiency virus type 1 (HIV-1) presents a significant barrier to the development of an effective and durable HIV vaccine. This variability not only makes it difficult to identify the targets against which immune responses should be directed, but it also confers on the virus the capacity for rapid escape from effective immune responses. Here, we describe recent investigations of the genetic diversity of HIV-1 at transmission and of the evolution of the virus as it adapts to the host immune environment during the acute phase of HIV-1 infection. These studies increase our understanding of the virology of the earliest stages of HIV-1 infection and provide critical insights into the mechanisms underlying viral replication and immune control of diverse HIV-1 strains. Such knowledge will inform the design of smarter, more effective vaccines capable of inducing immune control of HIV-1.

引用

页码：S309 / S314

页数：6

共 42 条

[1] Hitting HIV where it hurts: an alternative approach to HIV vaccine design [J].

Altfeld, Marcus ;

Allen, Todd M. .

TRENDS IN IMMUNOLOGY, 2006, 27 (11) :504-510

[2] Wide Variation in the Multiplicity of HIV-1 Infection among Injection Drug Users [J].

Bar, Katharine J. ;

Li, Hui ;

Chamberland, Annie ;

Tremblay, Cecile ;

Routy, Jean Pierre ;

Grayson, Truman ;

Sun, Chuanxi ;

Wang, Shuyi ;

Learn, Gerald H. ;

Morgan, Charity J. ;

Schumacher, Joseph E. ;

Haynes, Barton F. ;

Keele, Brandon F. ;

Hahn, Beatrice H. ;

Shaw, George M. .

JOURNAL OF VIROLOGY, 2010, 84 (12) :6241-6247

[3] Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes [J].

Barouch, DH ;

Kunstman, J ;

Kuroda, MJ ;

Schmitz, JE ;

Santra, S ;

Peyerl, FW ;

Krivulka, GR ;

Beaudry, K ;

Lifton, MA ;

Gorgone, DA ;

Montefiori, DC ;

Lewis, MG ;

Wolinsky, SM ;

Letvin, NL .

NATURE, 2002, 415 (6869) :335-339

[4] Accurate whole human genome sequencing using reversible terminator chemistry [J].

Bentley, David R. ;

Balasubramanian, Shankar ;

Swerdlow, Harold P. ;

Smith, Geoffrey P. ;

Milton, John ;

Brown, Clive G. ;

Hall, Kevin P. ;

Evers, Dirk J. ;

Barnes, Colin L. ;

Bignell, Helen R. ;

Boutell, Jonathan M. ;

Bryant, Jason ;

Carter, Richard J. ;

Cheetham, R. Keira ;

Cox, Anthony J. ;

Ellis, Darren J. ;

Flatbush, Michael R. ;

Gormley, Niall A. ;

Humphray, Sean J. ;

Irving, Leslie J. ;

Karbelashvili, Mirian S. ;

Kirk, Scott M. ;

Li, Heng ;

Liu, Xiaohai ;

Maisinger, Klaus S. ;

Murray, Lisa J. ;

Obradovic, Bojan ;

Ost, Tobias ;

Parkinson, Michael L. ;

Pratt, Mark R. ;

Rasolonjatovo, Isabelle M. J. ;

Reed, Mark T. ;

Rigatti, Roberto ;

Rodighiero, Chiara ;

Ross, Mark T. ;

Sabot, Andrea ;

Sankar, Subramanian V. ;

Scally, Aylwyn ;

Schroth, Gary P. ;

Smith, Mark E. ;

Smith, Vincent P. ;

Spiridou, Anastassia ;

Torrance, Peta E. ;

Tzonev, Svilen S. ;

Vermaas, Eric H. ;

Walter, Klaudia ;

Wu, Xiaolin ;

Zhang, Lu ;

Alam, Mohammed D. ;

Anastasi, Carole .

NATURE, 2008, 456 (7218) :53-59

[5] Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection [J].

Betts, MR ;

Exley, B ;

Price, DA ;

Bansal, A ;

Camacho, ZT ;

Teaberry, V ;

West, SM ;

Ambrozak, DR ;

Tomaras, G ;

Roederer, M ;

Kilby, JM ;

Tartaglia, J ;

Belshe, R ;

Gao, F ;

Douek, DC ;

Weinhold, KJ ;

Koup, RA ;

Goepfert, P ;

Ferrari, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (12) :4512-4517

[6] CTL escape mutations in gag epitopes restricted by protective HLA class I alleles cause substantial reductions in viral replication capacity [J].

Boutwell, C. L. ;

Schneidewind, A. ;

Brumme, Z. ;

Brockman, M. ;

Streeck, H. ;

Brumme, C. ;

Dudek, T. ;

Kane, K. ;

Kemper, M. ;

Walker, B. ;

Altfeld, M. ;

Allen, T. .

RETROVIROLOGY, 2009, 6

[7] Reduced Viral Replication Capacity of Human Immunodeficiency Virus Type 1 Subtype C Caused by Cytotoxic-T-Lymphocyte Escape Mutations in HLA-B57 Epitopes of Capsid Protein [J].

Boutwell, Christian L. ;

Rowley, Christopher F. ;

Essex, M. .

JOURNAL OF VIROLOGY, 2009, 83 (06) :2460-2468

[8] Escape and compensation from early HLA-B57-Mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A [J].

Brockman, Mark A. ;

Schneidewind, Arne ;

Lahaie, Matthew ;

Schmidt, Aaron ;

Miura, Toshiyuki ;

DeSouza, Ivna ;

Ryvkin, Faina ;

Derdeyn, Cynthia A. ;

Allen, Susan ;

Hunter, Eric ;

Mulenga, Joseph ;

Goepfert, Paul A. ;

Walker, Bruce D. ;

Allen, Todd M. .

JOURNAL OF VIROLOGY, 2007, 81 (22) :12608-12618

[9] Escape from autologous humoral immunity of HIV-1 is not associated with a decrease in replicative capacity [J].

Bunnik, Evelien M. ;

Lobbrecht, Marilie S. D. ;

van Nuenen, Ad C. ;

Schuitemaker, Hanneke .

VIROLOGY, 2010, 397 (01) :224-230

[10] Selection for human immunodeficiency virus type I envelope glycosylation variants with shorter V1-V2 loop sequences occurs during transmission of certain genetic subtypes and may impact viral RNA levels [J].

Chohan, B ;

Lang, D ;

Sagar, M ;

Korber, B ;

Lavreys, L ;

Richardson, B ;

Overbaugh, J .

JOURNAL OF VIROLOGY, 2005, 79 (10) :6528-6531

← 1 2 3 4 5 →