Wide Variation in the Multiplicity of HIV-1 Infection among Injection Drug Users

被引：154

作者：

Bar, Katharine J. ^{[1
]}

Li, Hui ^{[1
]}

Chamberland, Annie ^{[2
]}

Tremblay, Cecile ^{[3
]}

Routy, Jean Pierre ^{[4
,5
]}

Grayson, Truman ^{[1
]}

Sun, Chuanxi ^{[1
]}

Wang, Shuyi ^{[1
]}

Learn, Gerald H. ^{[1
]}

Morgan, Charity J. ^{[1
]}

Schumacher, Joseph E. ^{[1
]}

Haynes, Barton F. ^{[6
]}

Keele, Brandon F. ^{[7
]}

Hahn, Beatrice H. ^{[1
]}

Shaw, George M. ^{[1
]}

机构：

[1] Univ Alabama, Birmingham, AL 35294 USA

[2] CHUM, Ctr Rech, Montreal, PQ, Canada

[3] Univ Montreal, Montreal, PQ, Canada

[4] McGill Univ, Ctr Hlth, Immunodeficiency Serv, Montreal, PQ, Canada

[5] McGill Univ, Ctr Hlth, Div Hematol, Montreal, PQ, Canada

[6] Duke Univ, Med Ctr, Durham, NC 27710 USA

[7] NCI, SAIC Frederick, Frederick, MD 21701 USA

来源：

JOURNAL OF VIROLOGY | 2010年 / 84卷 / 12期

基金：

比尔及梅琳达.盖茨基金会; 加拿大健康研究院; 美国国家卫生研究院;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; COCAINE CO-USE; SELECTIVE TRANSMISSION; RHESUS MACAQUES; MONTREAL; DIVERSITY; VARIANTS; VACCINE; TRIAL; RISK;

D O I：

10.1128/JVI.00077-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recent studies indicate that sexual transmission of human immunodeficiency virus type 1 (HIV-1) generally results from productive infection by only one virus, a finding attributable to the mucosal barrier. Surprisingly, a recent study of injection drug users (IDUs) from St. Petersburg, Russia, also found most subjects to be acutely infected by a single virus. Here, we show by single-genome amplification and sequencing in a different IDU cohort that 60% of IDU subjects were infected by more than one virus, including one subject who was acutely infected by at least 16 viruses. Multivariant transmission was more common in IDUs than in heterosexuals (60% versus 19%; odds ratio, 6.14; 95% confidence interval [CI], 1.37 to 31.27; P = 0.008). These findings highlight the diversity in HIV-1 infection risks among different IDU cohorts and the challenges faced by vaccines in protecting against this mode of infection.

引用

页码：6241 / 6247

页数：7

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