Poly(ethylene glycol) conjugated nano-graphene oxide for photodynamic therapy

被引：75

作者：

Dong HaiQing ^{[1
]}

Zhao ZhiLei ^{[1
]}

Wen HuiYun ^{[1
]}

Li YongYong ^{[1
]}

Guo FangFang ^{[1
]}

Shen AiJun ^{[1
]}

Frank, Pilger ^{[1
]}

Lin Chao ^{[1
]}

Shi DongLu ^{[1
,2
]}

机构：

[1] Tongji Univ, Inst Adv Mat & Nano Biomed iNANO, Shanghai 200092, Peoples R China

[2] Univ Cincinnati, Dept Chem & Mat Engn, Cincinnati, OH 45221 USA

来源：

SCIENCE CHINA-CHEMISTRY | 2010年 / 53卷 / 11期

关键词：

nano-graphene oxide; photodynamic therapy; photosensitizer; drug delivery; biomedical application; DELIVERY; CARBON; PHOTOSENSITIZERS; CANCER;

D O I：

10.1007/s11426-010-4114-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel methoxy-poly(ethylene glycol) modified nano-graphene oxide (NGO-mPEG) was designed and synthesized as a photosensitizer (PS) carrier for photodynamic therapy of cancer. NGO with a size below 200 nm was prepared using a modified Hummers' method. NGO was observed by AFM to exhibit a structure with single-layer graphene oxide sheets down to a few nanometers in height. Hydrophilic mPEG conjugation of NGO (NGO-mPEG) was found to enhance solubility in cell culture media. No apparent cytotoxicity of the NGO-mPEG was observed towards MCF-7 carcinoma cell line. Zinc phthalocyanine (ZnPc), a photosensitizer for photodynamic therapy, was loaded in the NGO-PEG through pi-pi stacking and hydrophobic interactions, with the drug loading efficiency up to 14 wt%. Hydrophobic ZnPc was internalized in MCF-7 cells, exhibiting a pronounced phototoxicity in the cells under Xe light irradiation. The results indicate a great potential of NGO-mPEG for photodynamic therapy of cancer.

引用

页码：2265 / 2271

页数：7

共 25 条

[1] Honeycomb Carbon: A Review of Graphene [J].

Allen, Matthew J. ;

Tung, Vincent C. ;

Kaner, Richard B. .

CHEMICAL REVIEWS, 2010, 110 (01) :132-145

[2] Electronic confinement and coherence in patterned epitaxial graphene [J].

Berger, Claire ;

Song, Zhimin ;

Li, Xuebin ;

Wu, Xiaosong ;

Brown, Nate ;

Naud, Cecile ;

Mayou, Didier ;

Li, Tianbo ;

Hass, Joanna ;

Marchenkov, Atexei N. ;

Conrad, Edward H. ;

First, Phillip N. ;

de Heer, Wait A. .

SCIENCE, 2006, 312 (5777) :1191-1196

[3]

Cynthia M., 2001, J PORPHYR PHTHALOCYA, V5, P161

[4] Liposomes for photodynamic therapy [J].

Derycke, ASL ;

de Witte, PAM .

ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (01) :17-30

[5] Comparison of the photophysics of an aggregating and non-aggregating aluminium phthalocyanine system incorporated into unilamellar vesicles [J].

Dhami, S ;

Phillips, D .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 1996, 100 (1-3) :77-84

[6] Photodynamic therapy for cancer [J].

Dolmans, DEJGJ ;

Fukumura, D ;

Jain, RK .

NATURE REVIEWS CANCER, 2003, 3 (05) :380-387

[7]

DOUGHERTY TJ, 1978, CANCER RES, V38, P2628

[8] The chemistry of graphene oxide [J].

Dreyer, Daniel R. ;

Park, Sungjin ;

Bielawski, Christopher W. ;

Ruoff, Rodney S. .

CHEMICAL SOCIETY REVIEWS, 2010, 39 (01) :228-240

[9] Modeling of a type II photofrin-mediated photodynamic therapy process in a heteroqeneous tissue phantom [J].

Hu, XH ;

Feng, YM ;

Lu, JQ ;

Allison, RR ;

Cuenca, RE ;

Downie, GH ;

Sibata, CH .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2005, 81 (06) :1460-1468

[10] State of the art in the delivery of photosensitizers for photodynamic therapy [J].

Konan, YN ;

Gurny, R ;

Allémann, E .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2002, 66 (02) :89-106

← 1 2 3 →