Side effects of genome structural changes

被引：72

作者：

Reymond, Alexandre

Henrichsen, Charlotte N.

Harewood, Louise

Merla, Giuseppe

机构：

[1] Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland

[2] IRCCS Casa Sollievo Sofferenza, Serv Genet Med, I-71013 San Giovanni Rotondo, Italy

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2007年 / 17卷 / 05期

关键词：

D O I：

10.1016/j.gde.2007.08.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The first extensive catalog of structural human variation was recently released. It showed that large stretches of genomic DNA that vary considerably in copy number were extremely abundant. Thus it is conceivable that they play a major role in functional variation. Consistently, genomic insertions and deletions were shown to contribute to phenotypic differences by modifying not only the expression levels of genes within the aneuploid segments but also of normal copy-number neighboring genes. In this report, we review the possible mechanisms behind this latter effect.

引用

页码：381 / 386

页数：6

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