Structural biology of glycoprotein hormones and their receptors

被引：29

作者：

Fan, QR

Hendrickson, WA

机构：

[1] Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA

[2] Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA

来源：

ENDOCRINE | 2005年 / 26卷 / 03期

关键词：

glycoprotein hormones; G protein-coupled receptors; follicle stimulating hormone-receptor complex; crystal structure;

D O I：

10.1385/ENDO:26:3:179

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glycoprotein hormones regulate reproduction in vertebrates and exert their actions through specific G protein-coupled receptors on target cell surfaces. Structural information is now available for human chorionic gonadotropin (CG), follicle-stimulating hormone (FSH), and FSH bound to the extracellular binding domain of its receptor (FSHRHB). The recently determined structure of a human FSH-FSHRHB complex provides an explanation for the specificity of glycoprotein hormones binding to their receptors, and it suggests hypotheses concerning the mechanism of transmembrane signal transduction.

引用

页码：179 / 188

页数：10

共 65 条

[41] Co-expression of defective luteinizing hormone receptor fragments partially reconstitutes ligand-induced signal generation [J].