Diversification of CDK11 transcripts during chicken testis development and regression

被引：7

作者：

Francone, VP ^{[1
]}

Mezquita, J ^{[1
]}

机构：

[1] Univ Barcelona, Fac Med, IDIBAPS, Lab Genet Mol,Dept Ciencias Fisiol 1, Barcelona, Spain

来源：

MOLECULAR REPRODUCTION AND DEVELOPMENT | 2005年 / 72卷 / 03期

关键词：

PITSLRE; CDK; cyclin-dependent kinase; spermatogenesis; polyadenylation; apoptosis;

D O I：

10.1002/mrd.20355

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CDK11 (cyclin-dependent kinase 11, formerly known as PITSLRE) is a serine/threonine kinase that associates with the cyclin L2 regulatory partner. CDK11 catalytic activity has been associated with apoptosis, transcription, and RNA processing. Here, we identify novel chicken testis CDK11 transcripts that differ in their 5'UTR, 3'UTR, splicing of the exon 6, and polyadenylation. We have also characterized the differential expression of CDK11 in somatic tissues, during testis development and upon testicular regression by diethylstilbestrol (DES) treatment. The heterogeneity of CDK11 transcripts presented in this study suggests new possibilities for post-transcriptional regulation.

引用

页码：273 / 280

页数：8

共 39 条

[1]

[Anonymous], [No title captured], DOI 10.1007/978-94-011-4485-8_2

[2]

Arias WM, 2000, J CELL BIOCHEM, V79, P15, DOI 10.1002/1097-4644(2000)79:1<15::AID-JCB30>3.0.CO

[3]

2-4

[4] Post-transcriptional regulation of gene expression by degradation of messenger RNAs [J].

Bevilacqua, A ;

Ceriani, MC ;

Capaccioli, S ;

Nicolin, A .

JOURNAL OF CELLULAR PHYSIOLOGY, 2003, 195 (03) :356-372

[5] The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis [J].

Chen, S ;

Yin, XL ;

Zhu, XY ;

Ji, SY ;

Chen, C ;

Cai, MM ;

Zhang, SW ;

Zong, HL ;

Hu, Y ;

Yuan, ZH ;

Shen, ZH ;

Gu, JX .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (22) :20029-20036

[6] Identification and characterization of a novel cell cycle-regulated internal ribosome entry site [J].

Cornelis, S ;

Bruynooghe, Y ;

Denecker, G ;

Van Huffel, S ;

Tinton, S ;

Beyaert, R .

MOLECULAR CELL, 2000, 5 (04) :597-605

[7] HuD binds to three AU-rich sequences in the 3′-UTR of neuroserpin mRNA and promotes the accumulation of neuroserpin mRNA and protein [J].

Cuadrado, A ;

Navarro-Yubero, C ;

Furneaux, H ;

Kinter, J ;

Sonderegger, P ;

Muñoz, A .

NUCLEIC ACIDS RESEARCH, 2002, 30 (10) :2202-2211

[8] Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain -: Phosphorylation by DYRK1A and colocalization with splicing factors [J].

de Graaf, K ;

Hekerman, P ;

Spelten, O ;

Herrmann, A ;

Packman, LC ;

Büssow, K ;

Müller-Newen, G ;

Becker, W .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (06) :4612-4624

[9]

DICKINSON L, 2002, J BIOL CHEM

[10] REDUCTION OF BACKGROUND PROBLEMS IN NONRADIOACTIVE NORTHERN AND SOUTHERN BLOT ANALYSES ENABLES HIGHER SENSITIVITY THAN P-32 BASED HYBRIDIZATIONS [J].

ENGLERBLUM, G ;

MEIER, M ;

FRANK, J ;

MULLER, GA .

ANALYTICAL BIOCHEMISTRY, 1993, 210 (02) :235-244

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