Fluoroolefin containing dipeptide isosteres as inhibitors of dipeptidyl peptidase IV (CD26)

被引：111

作者：

Welch, JT

Lin, J

机构：

[1] Department of Chemistry, University at Albany, Albany

来源：

TETRAHEDRON | 1996年 / 52卷 / 01期

关键词：

D O I：

10.1016/0040-4020(95)00912-R

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(Z)-(S)Ala-psi[CF=C]-(RS)-Pro containing N,O-diacylhydroxamic acid type protease inhibitors have been prepared for the study of the influence of prolylamide bond geometry on the inhibition of dipeptidyl peptidase IV(CD26). The synthesis is based upon the use of tert-butyl alpha-fluoro-alpha-trimethylsilylacetate in a variation of the Peterson olefination procedure to construct the necessary functionalized fluoroolefin.

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页码：291 / 304

页数：14

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