Cancer proteomics by quantitative shotgun proteomics

被引：67

作者：

Chen, Emily I. ^{[1
]}

Yates, John R., III ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

来源：

MOLECULAR ONCOLOGY | 2007年 / 1卷 / 02期

关键词：

Quantitative proteomics; Shotgun proteomics; Mass spectrometry; Cancer cells; Protein profiling;

D O I：

10.1016/j.molonc.2007.05.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A major scientific challenge at the present time for cancer research is the determination of the underlying biological basis for cancer development. It is further complicated by the heterogeneity of cancer's origin. Understanding the molecular basis of cancer requires studying the dynamic and spatial interactions among proteins in cells, signaling events among cancer cells, and interactions between the cancer cells and the tumor microenvironment. Recently, it has been proposed that large-scale protein expression analysis of cancer cell proteomes promises to be valuable for investigating mechanisms of cancer transformation. Advances in mass spectrometry technologies and bioinformatics tools provide a tremendous opportunity to qualitatively and quantitatively interrogate dynamic protein-protein interactions and differential regulation of cellular signaling pathways associated with tumor development. In this review, progress in shotgun proteomics technologies for examining the molecular basis of cancer development is presented and discussed. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved

引用

页码：144 / 159

页数：16

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